Oligo Chitosan as Natural Super Anti-Microbial Agent COS-LM at 50ppm inhibits most Gram (+) & many Gram (-)

・Food & Beverage
・Water Sanitation
・Wound Dressings
・Medical Devices
・Produce (Fruits & Vegetables)

Chitosan is a natural biopolymer produced by the deacetylation of chitin, a major component of the shells of crustaceans such as crab, shrimp, and crawfish. A previous study indicates that Chitosan generally shows stronger bactericidal effects with Gram-positive than Gram-negative bacteria at the MIC (Minimum Inhibition Concentration) in 500~1000 ppm depending on the bacteria and molecular weight. Although chitosan is known to have important functional activities, poor water solubility makes it difficult to use in food and medicinal applications. Chitosan oligosaccharides (COS), also called oligo chitosan or chitooligosaccharides, are normally enzymatic products hydrolyzed from chitosan. COS which have a degree of polymerization (DP) between 2~20 (Mw: 0.4~4kDa), are water soluble and have attracted the interest of many pharmaceutical, food and nutrition researchers.

There are many indications that COS may be developed as drugs against asthma and as ingredients in wound-dressings and vectors in gene-therapy. Furthermore, COS can reduce metastasis and tumor-growth in cancer and increase bone-strength in osteoporosis. It also plays a role in immune modulation and serum glucose regulation. Other advantages also include hypocholesterolemic, anti-inflammatory, and antioxidant properties, but most importantly, a broad spectrum of antimicrobial activities. Some reports3 have indicated that the antimicrobial activity of COS & Low Molecular Weight Chitosan (LMWC) increased with the degree of polymerization (DP) depending on bacterial strain and DP.

COS-LM: Super antimicrobial activity in a category of its own!

1. 99.99% inhibition for most Gram (+) bacteria and many yeasts; >75% for many Gram (-)
2. Proprietary enzymatic hydrolysis process – Simple & Efficient Competitive    price .Excellent water solubility

COS-LM is a mixture of oligo chitosan (DP 2~20) and low molecular weight chitosan, LMWC (DP>21) with wider molecular weight distribution than the smaller COS-600 while retaining good water solubility. The COS-LM can effectively (>99.99%) inhibit the proliferation of most Gram (+) and yeasts (Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Candida utilis, Saccharomyces cerevisiae etc.) at 50ppm. It also reduces the growth (63~80%) of many of Gram (-) microbials such as E. coli, and Pseudomonas aeruginosaetc, Vibrio parahaemolyticus at 50~200 ppm level, ranking it among the best anti-microbial agents in its category. These characteristics can be leveraged for medical devices and wound-healing dressings. Since COS & LMWC have an unpleasant flavor, such as astringency and after taste, the very low concentration at 50ppm is especially welcome when they are used as a natural antimicrobial agent in pharmaceutical, food, beverage, and water sanitation industries.