Medicinal Mycelia

 Fermented Antrodia camphorata (Ruby Mushroom®) Mycelia    

Antrodia camphorata (synonym: Antrodia cinnamomea), or Ruby Mushroom®, is a famous folk medicine exclusively from Taiwan. In the wild A. camphorata grows solely on the tree Cinnamomum kanehirai, a species of cinnamon that grows at altitudes of between 450 and 2,000m in the mountains of Taiwan. As the fruiting body only develops fully once the tree is dead, in the past many trees were felled to supply demand for this unique and extremely lucrative mushroom (wild A. camphorata fetches up to US$55,000/kg dry wt.) and this, coupled with the fact that C. kanehirai itself is highly sought for furniture manufacture, has led to over-exploitation, with the result that C. kanehirai is now protected by the Taiwanese government

To replace the wild-collected material, commercial cultivation of A. camphorata has been developed using a variety of techniques to produce either cultivated fruiting body, pure mycelium (grown by liquid fermentation), or mycelial biomass (mycelium and residual substrate). Levels of triterpenes are highest in the fruiting body products, which are also the most expensive, with liquid fermentation mycelial products offering a cost-effective intermediate option.

To fulfill the demand, Simpson Biotech not only successfully uses a sub-merge process to ferment the mycelia with a very high (~12%) content but also solely owns all the IP of the active compounds Hepasim®.

Other fermented mycelia of medicinal fungus:

Cordycep sinensis mycelia  

Cordyceps sinensis is the Cordyceps species most widely used as a dietary supplement. Cordyceps sinensis is a fungus that naturally grows on the back of caterpillars. The Cordyceps fungus replaces the caterpillar tissue, eventually growing on the top of the caterpillar. The remaining structures of the caterpillar along with the fungus are dried and sold as the dietary supplement cordyceps.

Commonly known as dong chong xia cao (summer-plant, winter-worm) in Chinese, cordyceps has been used as a food supplement and tonic beverage among the rich because of its short supply. Cordyceps is also an ingredient in soups and foods used traditionally in Chinese medicine to help people recover from illness.

Cordyceps sinensis mycelia (CSM) and their extracts

Ruby MaleMaxTM: male hormone stimulator
(In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells)
(In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse)
(Cordyceps sinensis and Its Fractions Stimulate MA-10 Mouse Leydig Tumor Cell Steroidogenesis)
(Effects of Cordyceps sinensis on testosterone production in normal mouse Leydig cells)

Ruby ImmuSimtm: immune booster
(Abrogation of streptococcal pyrogenic exotoxin B-mediated suppression of phagocytosis in U937 cells by Cordyceps  sinensis mycelium via production of cytokines)
(Cordyceps sinensis mycelium protects mice from group A streptococcal infection)

Ruby Osterosimtm: anti-osteoporosis agent (US Pat. 7311919)
(Agents for treating osteoporosis and inhibiting osteoclast formation.)

Mycelia of Phellinus linteus, Ganoderma lucidum, Agaricus blazei Murill and their extracts