Super Antimicrobial Chitosan-Water Soluble
- Low Moleculer Chitosan (COS-LM) eliminates most bacteria and certain yeasts at 15-62ppm
- Application: Pharmaceuticals, Food & Beverage, Aquaculture, Detergents, Wound Dressings, Medical Devices, Cosmetics, Water Sanitation, Textiles/Diapers/Napkins, Produce (Fruits & Vegetables)
Chitosan is a natural biopolymer produced by the deacetylation of chitin, a major component of the shells of crustaceans such as crab, shrimp, and crawfish. A previous study indicates that Chitosan generally shows stronger bactericidal effects with Gram-positive than Gram-negative bacteria at the MIC (Minimum Inhibition Concentration) in 500~1000 ppm depending on the bacteria and molecular weight. Although chitosan is known to have important functional activities, poor water solubility makes it difficult to use in food and medicinal applications. Chitosan oligosaccharides (COS), also called oligo chitosan or chitooligosaccharides, are normally enzymatic products hydrolyzed from chitosan. COS which have a degree of polymerization (DP) between 2~20 (Mw: 0.4~4kDa), are water soluble and have attracted the interest of many pharmaceutical, food and nutrition researchers.
There are many indications that COS may be developed as drugs against asthma and as ingredients in wound-dressings and vectors in gene-therapy. Furthermore, COS can reduce metastasis and tumor-growth in cancer and increase bone-strength in osteoporosis. It also plays a role in immune modulation and serum glucose regulation. Other advantages also include hypocholesterolemic, anti-inflammatory, and antioxidant properties, but most importantly, a broad spectrum of antimicrobial activities. Some reports have indicated that the antimicrobial activity of COS & Low Molecular Weight Chitosan (LMWC) increased with the degree of polymerization (DP) depending on bacterial strain and DP.
COS-LM: The best antimicrobial chitosan in its own category!
- 99.99% inhibition for most bacteria and certain yeasts.
- Proprietary enzymatic hydrolysis process-Simple & Efficient → Competitive price
- Excellent water solubility (>10%)
Simpson Biotech’s COS-LM is a mixture of water soluble COS & Low Molecular Weight Chitosan (LMWC) that effectively eliminates most bacteria (Gram positive or negative) and certain yeasts (see table) even at 50ppm, ranking it among the best anti-microbial agents in its category. Considering that most working concentrations of most chitosan commodities are between 500~1000ppm, the 15-62ppm working concentration (inhibition rate >99.99%) of Simpson Biotech’s COS-LM stands in a category of its own! These characteristics can be leveraged for personal hygiene products, medical devices and wound-healing dressings. The extremely low concentration (like 15ppm) avoids generating any unpleasant flavor, such as astringency, when Simpson Biotech’s COS-LM are used as a natural antimicrobial agent in pharmaceutical, food, beverage and water sanitation industries.
Antibacterial test on nonwoven fabric: